化学信息： 化学名 N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide 简称 PNU282987 别名 PNU 282987, PNU-282987 中文名 N/A 化学式 C14H18Cl2N2O 分子量 301.21 CAS号 123464-89-1 纯度 98% 溶剂/溶解度 Water<1mg/ml; DMSO61mg/ml; Ethanol<1mg/ml 溶液配制 5mg加入1.66ml DMSO，或者每3.01mg加入1ml DMSO，配制成10mM溶液。SF9020-10mM用DMSO配制。 生物信息： 产品描述 PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50≥60μM). 信号通路 Transmembrane Transporters; Neuronal Signaling 靶点 α7 nAChR agonist － － － － IC50 26nM(Ki) － － － － 体外研究 Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion. 体内研究 Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6 and 12h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R. Mice treated with 2.5 and 10mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min). 临床实验 N/A 特征 N/A 相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)： 酶活性检测实验 方法 N/A 细胞实验 细胞系 N/A 浓度 N/A 处理时间 N/A 方法 N/A 动物实验 动物模型 N/A 配制 N/A 剂量 N/A 给药方式 N/A 参考文献： 1. Bodnar AL, et al. J Med Chem. 2005 Feb 24, 48(4), 905-8. 2. Li F, et al. Shock. 2013 Feb, 39(2), 197-203. 3. Stuckenholz V, et al. J Parkinsons Dis. 2013, 3(2), 161-72. 4. Mesa-Gresa P, et al. Behav Processes. 2014 Mar, 103, 117-24.

保存条件：-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。

注意事项：
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。


为了您的安全和健康，请穿实验服并戴一次性手套操作。